S Nick Collins, Rd. 2 in 2005
Struck down by a career-ending neck injury in early 2011, he had just turned 28 and was at the height of his career. From 2008-10, he received three consecutive All-Pro and Pro Bowl honors and the expectation was there were many more to come. Collins was as good a tackler as he was a pass defender. Collins was also a game-changer, the most memorable example being his pick-6 of Ben Roethlisberger in Super Bowl XLV.